Cardiomyocyte cytoskeleton in dilated cardiomyopathy and ischemic heart disease
Beletskaia, L.V.; Zhbanova, L.B.; Zaĭdenov, V.A.; Kurenkova, L.G.; Riaboshtanova, E.I.
Arkhiv Patologii 58(2): 45-49
1996
ISSN/ISBN: 0004-1955 PMID: 8712941 Document Number: 465828
Summary, Vinculin, the protein of cardiomyocyte cytoskeleton in the myocardium of patients with a dilated cardiomyopathy and ischemic heart disease, was revealed by means of monoclonal antibodies and by a method of indirect immunofluorescence. Cytoskeleton of patients with dilated cardiomyopathy is disorganized, hypertrophic and contains greater amounts of vinculin than cytoskeleton and normal cardiomyocytes. this most likely negatively influences cell contractile capacity. The vinculin content was also higher in cardiomyocyte cytoskeleton of patients with ischemic heart disease but at a less degree than in patients with dilated cardiomyopathy.