Impairment of myocardial perfusion reserve in microvascular angina (syndrome X) : assessment by 99mTc-MIBI-SPECT
Langes, K.; Beuthien-Baumann, B.; Lübeck, M.; Fuchs, C.; Schneider, M.A.; Volk, C.; Nienaber, C.A.
Nuklearmedizin. Nuclear Medicine 35(6): 193-197
1996
ISSN/ISBN: 0029-5566 PMID: 8999418 Document Number: 465393
In 22 patients with typical chest pain and normal coronary arteries (microvascular angina, syndrome X) 99mTc-MIBI-SPECT was examined in regard to assess impairment of myocardial perfusion reserve. The study was performed with 99mTc-MIBI-SPECT at rest and under vasodilation with dipyridamole. The findings were compared with a normal database. A normal perfusion reserve was said to be an increase > 20% of the 99mTc-MIBI-activity. In 2/22 (9%) of the patients the perfusion reserve lay > 20% i.e. 37%. In 91% of the patients a diminution or even decrease of the perfusion was to be seen. From these 9/22 (41%) of the patients showed a diminution of the 99mTc-MIBI-uptake by 6%. 1/22 patients had a decrease of the perfusion under vasodilation with dipyridamole i.e. a lower activity of 99mTc-MIBI by 13% Vasodilation 99mTc-MIBI-SPECT offers good imaging quality and enables semi-quantitative assessment of myocardial perfusion reserve in patients with microvascular angina.