Steryl cellosolves--regulators of cholesterol metabolism in isolated rabbit hepatocytes
Maliugin, A.V.; Shteĭnshneĭder, A.I.; Kosykh, V.A.; Alquier, C.; Lafont, H.; Misharin, A.I.
Bioorganicheskaia Khimiia 22(8): 606-610
1996
ISSN/ISBN: 0132-3423 PMID: 8985004 Document Number: 465367
Synthesis of 3 beta-(2-hydroxyethoxy)cholest-5-ene, 3 beta-(2-hydroxyethoxy)cholest-5-en-7-one, 3 beta-(2-hydroxyethoxy)-7 beta-hydroxycholest-5-ene, 3 beta-(2-hydroxyethoxy)-5 alpha, 6 alpha-epoxycholestane, and 3 beta-(2-hydroxyethoxy) -5 alpha, 6 beta-dihydroxycholestane was described. Substances obtained inhibited cholesterol biosynthesis in the rabbit hepatocyte cell culture with ID 50 from 5.5(+/-0.7) x 10(-8) to 1.3(+/-0.2) x 10(-5) M and also to a remarkable extent the cell protein biosynthesis.