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Inhibition of cholesterol biosynthesis in rabbit hepatocytes by 3-beta- (omega-hydroxyalkoxy) cholest-5-enes

Maliugin, A.V.; Novikov, D.K.; Kosykh, V.A.; Kosenkov, E.I.; Medvedeva, N.V.; Valentinova, N.V.; Shteĭnshneĭder, A.Ia.; Misharin, A.Iu.

Bioorganicheskaia Khimiia 22(7): 541-547

1996

ISSN/ISBN: 0132-3423
PMID: 8992960
Document Number: 463672
3-beta-(2-Hydroxyethoxy)-, 3-beta-(4-hydroxybutoxy)-, 3-beta-(6-hydroxyhexyloxy)-, 3-beta-(9-hydroxynonyloxy)-, and 3-beta-(2-hydroxy-2-(3H)ethoxy)cholest-5-enes were synthesized. By means of a spin probe, the influence of the synthesized compounds on the phase transition of dimyristoylphosphatidylcholine were estimated. Time and dose dependences of the incorporation of 3-beta-(2-hydroxy-2-(3H)ethoxy)cholest-5-ene into rabbit hepatocytes (the primary culture) were studied. 3-beta-(2-Hydroxyethoxy)- and 3-beta-(4-hydroxybutoxy)cholest-5-enes were shown to inhibit cholesterol biosynthesis from (14C)acetate in rabbit hepatocyte cultures upon a 24-hour preincubation.

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