Immunophenotyping in the differential diagnosis of malignant non-hodgkin's lymphomas

Dzembak, T.M.; Gurkalo, V.K.; Gershanovich, M.L.

Voprosy Onkologii 42(5): 63-66

1996


ISSN/ISBN: 0507-3758
PMID: 9064906
Document Number: 465151
Non-Hodgkin's malignant lymphoma was diagnosed in 66 patients by immunophenotype technique using a batch of 13 Russian-isolated monoclonal antibodies which help identify antigens of T- and B-lymphocyte surface membranes. Polyclonal light chains of immunoglobulins and T- and B-cell antigens were identified in the course of histological examination of biopsy material sampled from hyperplasia lymphoid tissue. B-cell lymphomas revealed monoclonal light chains of immunoglobulins and positive B-cell antigens. T-cell tumors had mostly T-cell antigens and no light chains of immunoglobulins. Neither common leukocyte antigen, nor panT- or panB-cell antigens were found in 7 cases of cancer metastasis to lymph nodes.

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