Suppression of systemic lupus erythematosus by the human immunodeficiency virus
Byrd, V.M.; Sergent, J.S.
Journal of Rheumatology 23(7): 1295-1296
1996
ISSN/ISBN: 0315-162X PMID: 8823711 Document Number: 465075
We describe a patient with refractory systemic lupus erythematosus (SLE) who demonstrated complete resolution of all SLE symptoms. He was subsequently found to be infected with the human immunodeficiency virus (HIV-1) and had marked depletion of peripheral CD4 positive T lymphocytes. In addition, while his SLE remained completely inactive, the course of HIV was rapidly progressive, suggesting that retroviral replication may have been enhanced by the underlying state of T cell transactivation characteristic of SLE.
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