Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro
Lin, J.H.; Hu, G.Y.; Tang, X.C.
Zhongguo Yao Li Xue Bao 17(4): 299-301
1996
ISSN/ISBN: 0253-9756 PMID: 9812706 Document Number: 463350
AIM: To study the effects of huperzine-A on neuromuscular junction transmission in mouse. METHODS: The isolated mouse phrenic nerve-hemidiaphragm preparations were used with the conventional intracellular recording technique. The spontaneous electrical activities of cholinergic nerve terminals (miniature end-plate potentials, MEPP) were recorded. RESULTS: Huperzine-A, tacrine, and E2020 at the concentrations of 0.05-1 mu-mol cntdot L-1 increased the amplitude, mean rise time, and half decay time of MEPP in a concentration-dependent manner. Their potencies were E2020 gt huperzine-A gt tacrine. CONCLUSION: The anticholinesterase action of huperzine-A in cholinergic synapses is stronger than that of tacrine.