The hyperbaric oxygen therapy of disordered ammonia detoxication in the operated liver
Savilov, P.N.
Anesteziologiia i Reanimatologiia 5: 64-67
1996
ISSN/ISBN: 0201-7563 PMID: 9027261 Document Number: 463318
The status of the main routes of ammonium detoxication in the liver (synthesis of glutamine and urea) after its resection and hyperbaric oxygenation (HBO) was studied in 160 rats. HBO (3 sessions at 3 atm. abs.--50 min) following resection of the liver stimulated the activity of glutamine synthase and prevented the reduction of glutamate (a substrate for glutamine synthesis) level in the operated on liver. Hyperbaric oxygen activated the glutamine-dependent and non-glutamine-dependent pathways of urea synthesis in the resected liver and ensured the incorporation of glutamine amido groups in the ornithine cycle. HBO boosted the inhibitory effect of liver resection on the activity of glutamate dehydrogenase and prevented the accumulation of ammonium in the hepatocytes of resected liver. The stimulating effect of HBO on the ammonium-detoxifying function of the resected liver persisted for 11 days after the exposure.