Autoantibodies against nerve tissue proteins long after cranio-cerebral injury
Morozov, S.G.; Asanova, L.M.; Gnedenko, B.B.; Panchenko, L.F.; Lavrova, T.N.
Voprosy Meditsinskoi Khimii 42(2): 147-152
1996
ISSN/ISBN: 0042-8809 PMID: 9148602 Document Number: 463254
20 samples of serum of patients with remote consequences of brain trauma were tested to detect autoantibodies (a-AB) against brain proteins S-100 and NKP. Essential pathology was not found out by standard solid-phase immunoassay. The original method was used to detect a-AB to the whole complex of antigen determinants. Using this method the elevation of a-AB against S-100 and NKP was shown at 16 cases. The disturbance of idiotype-antiidiotype regulation was revealed at this group of patients. It is suggested that insufficient level of corresponding antiidiotypes creates the conditions for autoimmune aggressor of a-AB against brain tissue.