Flare-up at contact allergy sites in a gold-treated rheumatic patient
Möller, H.; Larsson, A.; Björkner, B.; Bruze, M.; Hagstam, A.
Acta Dermato-Venereologica 76(1): 55-58
1996
ISSN/ISBN: 0001-5555 PMID: 8721495 Document Number: 462480
Contact allergy to gold sodium thiosulfate and gold sodium thiomalate was established by skin testing in a rheumatic patient intended for gold therapy. An intramuscular test dose of gold sodium thiomalate (Myocrisin) induced a flare-up of previously positive epicutaneous and intradermal test reactions, with a histological and immunohistochemical picture compatible with an allergic contact dermatitis. Since gold allergy is frequent, the cutaneous side-effects of gold therapy ("gold dermatitis") may be explained by such an immunopathological reaction.