Clinical importance of p53 gene mutation and PCNA expression in ureteral and renal pelvic cancers
Kong, C.; Liu, T.; Zhang, M.
Zhonghua Zhong Liu Za Zhi 18(6): 436-438
1996
ISSN/ISBN: 0253-3766 PMID: 9387296 Document Number: 461788
In order to know the clinical importance of p53 gene mutation and PCNA expression in ureteral and renal pelvic cancers, research was carried out with immunohistochemistry S-P method in 45 cases. Mutant p53 nuclear staining was positive in 24 cases (53.3%) and correlated with PCNA expression, being higher in clinical stages T-3 and T-4 than in T-1 + T-2. They also correlated with the grade of cell differentiation, being higher in G-3 than in G-1 + G-2.