Solitary rectal ulcer syndrome. Mucosal prolapse syndrome
Bogomoletz, W.V.
Pathology Annual 27 Pt 1: 75-86
1992
ISSN/ISBN: 0079-0184 PMID: 1736248 Document Number: 4612
Solitary rectal ulcer syndrome (SRUS) is an uncommon benign condition that predominantly affects young adults of either sex. Rectal bleeding is a common symptom. Typical histological features include crypt hyperplasia and fibromuscular obliteration of the rectal mucosa. The terms "solitary" and "ulcer" are both misleading, because sometimes there is more than one ulcer or the disease manifests itself in a variety of non-ulcerated lesions. Unfortunately, late complications of SRUS have often been mistaken for different conditions and described separately under confusing terms. Although SRUS is now a welldocumented entity, patients with this disease are still misdiagnosed, because of endoscopic and histological misinterpretation, and as a consequence, they are wrongly or inadequately treated. This review of the different clinicopathologic aspects of SRUS, with special emphasis on the histological features, is based on our experience with over 150 cases seen in our laboratory or referred to us for consultation, and on pertinent data from the literature.
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