Selected immune response parameters in respiratory tract infections in mice--effect of combined treatment with tienamycin and coparvax
Korczak, E.; Ciebiada, I.; Denys, A.
Pneumonologia i Alergologia Polska 64(5-6): 303-308
1996
ISSN/ISBN: 0867-7077 PMID: 8924882 Document Number: 460760
The combined model of viral/bacterial infections has been used in the study. Tienamycin and Coparvax have been administered to infected mice. During the time of 3, 6, 9 and 14 days the hemagglutination inhibition reactions, migration inhibition of leukocytes, phagocytic activity and killing effect of the peritoneal exudate granulocytes have been made. The analysis of migration inhibition of leukocytes gave a statistically characteristic answer after using antigen of anatoxin compared to influenza antigen. In the group of animals which were treated with tienamycin and Coparvax a higher percentage of migration inhibition was observed than in the other group are substantial in the reaction of phagocytosis. Generally, a more beneficial influence of the combined treatment with tienamycin and coparvax has been observed.