Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes

Haraguchi, H.; Ohmi, I.; Masuda, H.; Tamura, Y.; Mizutani, K.; Tanaka, O.; Chou, W.H.; Haraguchi, H; Ohmi, I; Masuda, H; Tamura, Y; Mizutani, K; Tanaka, O; Chou, W.H

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Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes

Haraguchi, H.; Ohmi, I.; Masuda, H.; Tamura, Y.; Mizutani, K.; Tanaka, O.; Chou, W.H.

Experientia 52(6): 564-567

1996

ISSN/ISBN: 0014-4754

PMID: 8698090

Document Number: 460243

Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against both dl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.