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ATGAM associated coagulopathy in renal transplant patients: a report of two unusual cases

Trivedi, H.S.; Lal, S.M.; Gupta, N.; Ross, G.

International Journal of Artificial Organs 19(8): 448-450

1996

ISSN/ISBN: 0391-3988
PMID: 8841842
Document Number: 459789
Polyclonal antibodies, used for both induction and rejection therapy in renal transplant recipients, are associated with such side effects as chills and fever. We describe two patients who developed a coagulopathy during antithymocyte globulin (ATGAM) therapy, a previously unknown complication. The laboratory tests revealed prolonged prothrombin and partial thromboplastin times and thrombocytopenia. Discontinuation of ATGAM therapy resulted in correction of these abnormalities.

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