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Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation

Bertheau, P.; Parquet, N.; Ferchal, F.; Gluckman, E.; Brocheriou, C.

Bone Marrow Transplantation 17(2): 295-298

1996

ISSN/ISBN: 0268-3369
PMID: 8640184
Document Number: 459463
Adenoviruses may cause severe infections in bone marrow transplant recipients. We report the case of a patient who developed fulminant hepatitis 5 months after bone marrow transplantation. Adenovirus type 2 was cultured from stool and blood samples. The patient died from liver failure. Histologic examination of post-mortem liver samples showed extensive necrosis with nuclear inclusions. Adenovirus was identified in liver cells by electron microscopy and immunohistochemical staining using a monoclonal anti-adenovirus antibody. No other pathogen was identified.

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