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Analysis of changes in human embryo fibroblasts with long-term exposure to drinking water in gastric cancer prevalent areas by flow cytometry

Gao, Z.; Gao, Z.; Wang, F.

Zhonghua Yu Fang Yi Xue Za Zhi 30(4): 199-201

1996

ISSN/ISBN: 0253-9624
PMID: 9388892
Document Number: 458964
Cell cycle distribution, cell proliferation index (PI) and DNA index (DI) were analyzed with flow cytometry (FCM) to study changes in human embryo fibroblast exposed to drinking water in gastric cancer prevalent areas for a long time. Results showed both proportion of cells in S and G-2M phases and PI increased significantly, DI were beyond its normal range, and cells revealed morphologically abnormal. It suggests drinking water in gastric cancer prevalent areas may contain carcinogenic substances, and correlate closely to high incidence of gastric cancer.

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