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The study of protective properties of attenuated strain of Argentinian hemorrhagic fever

Ignat'ev, G.M.; Blinov, V.M.; Romanowski, V.

Voprosy Virusologii 41(4): 158-161

1996

ISSN/ISBN: 0507-4088
PMID: 8999669
Document Number: 458866
Immunization of BALB/c, C57BL/6, CBA/calac mice with strain XJ44 of Argentine hemorrhagic fever resulted in changes of nonspecific immunity parameters, such as interferon, interleukin-1, tumor necrosis factor, and natural killers. The formation of a specific humoral and cellular immune response in BALB/c mice immunized with this strain has been demonstrated. Immunization of BALB/c mice with strain XJ44 protected the animals from infection with a heterogeneous strain Carvallo of Bolivian hemorrhagic fever.

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