Hormonal premedication in endometrium ablation--results of a prospective comparative study
Römer, T.; Müller, J.; Bojahr, B.; Schwesinger, G.; Lober, R.
Zentralblatt für Gynakologie 118(5): 291-294
1996
ISSN/ISBN: 0044-4197 PMID: 8701626 Document Number: 456872
In a prospective study in 40 patients the pretreatment for endometrial ablation with a gestagen (Orgametril 10 mg/die), danazol (600 mg/die) and an injection of a GnRH-analogon (Decapeptyl-Depot) was compared with a control group without pretreatment. The subjective estimation of the surgeon (endometrial thickness and depth of coagulation) showed a sufficient pretreatment in 90 % of all cases following danazol- and GnRH-analogon-pretreatment. In 90 % of the danazol- and GnRH-analogon pretreated group the histological findings showed also an atrophic or little proliferative endometrium. In a follow up of 6 months after endometrial ablation the highest amenorrhoea-rates were reached following danazol- and GnRH-analogon pretreatment. These two regimes should be used for the pretreatment for endometrial ablation.