A prospective cohort study of oral contraceptives and cancer of the endometrium
Trapido, E.J.
International Journal of Epidemiology 12(3): 297-300
1983
ISSN/ISBN: 0300-5771 PMID: 6629618 DOI: 10.1093/ije/12.3.297Document Number: 400296
A prospective cohort study of .apprx. 97,300 women was conducted in eastern Massachusetts, USA. Information on use of oral contraceptives, and on gynecological and reproductive histories was sought through mailed questionnaires, while new diagnosed cases of cancer of the endometrium were identified from records of 34 area hospitals. Oral conceptive (OC) use was associated with some increases in endometrial cancer rates (standardized rate ratio = 1.4; 95% confidence interval = 0.9-2.4) although the risk did not vary consistently by length of use, years since first use, or age at initial use. Although some subgroups of users had rates of disease higher than among nonusers, there was little to suggest a consistent association between OC use and incidence of endometrial cancer.