Selective transfection of animal cells by non viral vectors: polylysine carrying recognition signals
Monsigny, M.; Midoux, P.; Roche, A.C.; Legrand, A.; Mayer, R.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 190(1): 39-43
1996
ISSN/ISBN: 0037-9026 PMID: 8881267 Document Number: 456217
A process for the selective transfer of genes using glycosylated polylysine was established. Glycosylated polylysines and plasmid DNA form complexes which are taken up by cells expressing surface lectins recognizing the sugar moieties of glycosylated polylysines. Modifications made to this process allow for efficient and specific transfer in in vitro animal cell models.