Effect of hemin in treating hemorrhagic anemia and toxicity
You, K.S.; Wu, B.; Huang, Z.Q.; Zhang, C.; Pan, L.J.; Wu, G.T.; Zhao, Z.Q.; Huang, M.H.
Zhongguo Yao Li Xue Bao 17(3): 284-286
1996
ISSN/ISBN: 0253-9756 PMID: 9812760 Document Number: 456173
AIM: To study the effect of hemin in treating hemorrhagic anemia and toxicity. METHODS: Fifty rats with hemorrhagic anemia were randomly divided into 5 groups with different dosage of hemin (93, 168, 300 mg cntdot kg-1 cntdot d-1), ferrous gluconate (FG 300 mg cntdot kg-1 cntdot d-1), and water, ig for 7d. Twenty mice fed with hemin (6.0 g cntdot kg-1 cntdot d-1) in 24 h for observing acute toxicity effects. Long-term toxicity were observed in 80 rats given hemin (0.65, 1.3, 2.6 g cntdot kg-1 cntdot d-1) in 3 months. RESULTS: Hb of the rats of corresponding groups were 66 fwdarw 121, 71 fwdarw 141, 66 fwdarw 148, 69 fwdarw 140, and 67 fwdarw 112 g cntdot L-1. There were no adverse effects observed on acute toxicity test. No abnormalitis were found in hemogram, liver renal function test, and autopsy. CONCLUSION: Hemin had a better effect than FG and no adverse effect was found in hemin.