Sodium hyaluronate as a tool in strabismus surgery in rabbits
Fulga, V.; Koren, R.; Ezov, N.; Gal, R.; Nimrod, A.; Savir, H.
Ophthalmic Surgery and Lasers 27(3): 228-233
1996
ISSN/ISBN: 1082-3069 PMID: 8833128 Document Number: 456016
The authors tested whether coating tissue with sodium hyaluronate (Na-HA) reduced postoperative adhesions and accelerated the healing process in strabismus surgery. The surgical technique was tested during recession and resection operations performed on 30 rabbits and was compared with the use of NaCl 0.9%. Clinical, biomicroscopic examinations were performed on postoperative days 1, 2, 7, and 30 and histopathologic examinations were performed on postoperative days 2, 7, and 30. Clinically, there were no statistically significant differences between the study group and the control group. Also, there were no statistically significant differences between the two groups for most of the histopathologic criteria; however, new vessel formation was smaller with Na-HA than without it. Statistical significance was defined as P < .05. The authors found no significant positive effect of Na-HA on postoperative healing in rabbits.