Uterine papillary serous carcinoma and papillary endometrial carcinoma: analysis of clinical biological behaviors of 56 cases
Sun, X.; Shi, S.; Sheng, X.
Zhonghua Fu Chan Ke Za Zhi 31(1): 8-11
1996
ISSN/ISBN: 0529-567X PMID: 8758810 Document Number: 455957
To characterize the clinical biological behavior and the pathological morphology of uterine papillary serous carcinoma and papillary endometrial carcinoma. This is a retrospective analysis of 56 patients with papillary endometrial cancer treated at Cancer Hospital. Chinese Academy of Medical Sciences from January, 1981 to December, 1993. Of the 56 cases, 15 were uterine papillary serous carcinomas (UPSC), 41 papillary endometrial carcinomas (PEC). One hundred and sixty patients with endometrial adenocarcinoma (AC) were submitted as control group. 26.7% of UPSC, 14.6% of PEC and 5.6% of AC patients had stage III or IV by clinical examination (P < 0.05), whereas 53.3% of UPSC, 20.8% of PEC and 12.1% of AC patients has extrauterine disease at surgery (P < 0.01). Deep myometrial invasion occurred in 75.0% of UPSC, 41.7% of PEC, and 32.3% of AC patients (P < 0.01). An increasing gradient of 5 year survival rate (life table method) was observed from UPSC (45.7%) to PEC (61.9%) to AC (90.3%) in their early stage (stage I-II) (P < 0.01). Upper abdominal spread was a common finding in UPSC which had a high rate of persistent disease (46.2%). The pelvis was the predominant involving site in PEC with a high frequency of recurrence and metastasis (31.0%). The presence of papillary features in endometrial carcinoma is an important prognostic indicator. The prognosis of PEC is better than UPSC, but worse than AC.