Oral treatment of late Lyme borreliosis with a combination of roxithromycin and co-trimoxazole--a pilot study on 18 patients
Gasser, R.; Reisinger, E.; Sedaj, B.; Horvarth, R.; Seinost, G.; Keplinger, A.; Wendelin, I.; Klein, W.
Acta Medica Austriaca 23(3): 99-101
1996
ISSN/ISBN: 0303-8173 PMID: 8798283 Document Number: 455917
In this pilot trial, 18 patients participated in an investigation in which the combined therapy of co-trimoxazole and roxithromycin in late Lyme borreliosis was tested. The study has been performed as a result of earlier case reports in "The Lancet" where this combination has been used successfully in order to thwart late Lyme disease. The authors show that 76% of the patients recovered completely. In 2 patients, symptoms could be resolved with i.v. penicillin and 2 did not respond to any antibiotic therapy. These results show that oral therapy of co-trimoxazole and roxithromycin in combination provides similar results as i.v. antibiotics in earlier studies.