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Determination of free radical activity in workers at risk for styrene exposure

Kohout, J.; Holecek, V.; Machartová, V.; Racek, J.; Jerábek, Z.; Senft, V.

Vnitrni Lekarstvi 42(8): 537-539

1996

ISSN/ISBN: 0042-773X
PMID: 8967022
Document Number: 455425
The authors examined indicators of the effect of free radicals (MDA, SOD, GSHPx, selenium) in 38 workers exposed to styrene. They revealed a statistically significant (p < 0.01) correlation of SOD activity and the period of exposure to styrene and also a statistically significant correlation (p < 0.05) between urinary selenium excretion and the period of exposure to styrene as well as a statistically significant correlation (p < 0.01) between the MDA serum concentration and urinary selenium excretion. There is no statistically significant difference between the MDA plasma concentration among smokers and non-smokers, the SOD activity is significantly higher in non-smokers (p < 0.05). Based on the revealed findings the authors assume that free radicals may also play a part in the action of styrene on the organism.

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