Top Abstract Purchase Related
Home
>
Node
>
Subnode

Preclinical pharmacology of neuroleptics: focus on new generation compounds

Richelson, E.

Journal of Clinical Psychiatry 57(Suppl): 4-11

1996

ISSN/ISBN: 0160-6689
PMID: 8941166
Document Number: 455213
This article reviews the preclinical pharmacology of neuroleptics, with focus on the newer generation compounds: clozapine, risperidone, olanzapine, sertindole, and quetiapine. All of these newer compounds are considered to be atypical neuroleptics, based on certain criteria, which are reviewed. Several hypotheses about the molecular mechanisms that explain atypicality are considered. Finally, the in vitro receptor binding data presented for these and some older compounds are related to the therapeutic and adverse effects of these drugs.

Document emailed within 1 workday
Secure & encrypted payments

Richelson, E. 1994: The pharmacology of antidepressants at the synapse: focus on newer compounds Journal of Clinical Psychiatry 55(Suppl): 34-39; Discussion 40-1, 98-100
Worms, P. 1982: Behavioral pharmacology of the benzamides as compared to standard neuroleptics Advances in Biochemical Psychopharmacology 35: 7-16
Jann, M.W. 1998: Preclinical pharmacology of metrifonate PharmacoTherapy 18(2 Part 2): 55-67; Discussion: 79-82
Moore, N. 1998: Olanzapine: preclinical pharmacology and recent findings Nihon Shinkei Seishin Yakurigaku Zasshi 18(3): 91-95
Cohen, M.L.; Fuller, R.W.; Kurz, K.D.; Parli, C.J.; Mason, N.R.; Meyers, D.B.; Smallwood, J.K.; Toomey, R.E. 1988: Preclinical pharmacology of a new serotonergic receptor antagonist, LY281067 Journal of Pharmacology and Experimental Therapeutics 244(1): 106-112
Newman, R.A.; Fuentes, A.; Covey, J.M.; Benvenuto, J.A. 1994: Preclinical pharmacology of the natural marine product dolastatin 10 (NSC 376128) Drug Metabolism and Disposition: the Biological Fate of Chemicals 22(3): 428-432
Walton, M.I.; Gibson, W.; Aherne, G.W.; Lawrence, N.; Stephens, T.C.; Smith, M.N.; Jackman, A.L. 1996: Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice Journal of Pharmacology and Experimental Therapeutics 277(2): 909-916
Cushion, M.T.; Walzer, P.D. 2009: Preclinical drug discovery for new anti-pneumocystis compounds Current Medicinal Chemistry 16(20): 2514-2530
Yazdani, S.K.; Sheehy, A.; Nakano, M.; Nakazawa, G.; Vorpahl, M.; Otsuka, F.; Donn, R.S.; Perkins, L.E.; Simonton, C.A.; Kolodgie, F.D.; Virmani, R. 2013: Preclinical evaluation of second-generation everolimus- and zotarolimus-eluting coronary stents Journal of Invasive Cardiology 25(8): 383-390
Kaiser, B.; Kirchmaier, C.M.; Breddin, H.K.; Fu, K.; Fareed, J. 1999: Preclinical biochemistry and pharmacology of low molecular weight heparins in vivo--studies of venous and arterial thrombosis Seminars in Thrombosis and Hemostasis 25(Suppl 3): 35-42
Danhof, M.; Visser, S.A. G. 2002: Pharmaco-electroencephalography and pharmacokinetic-pharmacodynamic modeling in drug development: focus on preclinical steps Methods and Findings in Experimental and Clinical Pharmacology 24 Suppl D: 127-128
Chekman, I.S.; Tkachuk, V.V. 1984: Principles, methods and criteria for assessing the effectiveness of potentially cardiotonic compounds at the preclinical research stage Farmakologiia i Toksikologiia 47(6): 5-15
Sample, R.G. 1973: Pharmacology of contraceptive agents--new compounds with new problems? American Journal of Pharmacy and the Sciences Supporting Public Health 145(4): 142-145
Balfour, D.J. 2001: The pharmacology underlying pharmacotherapy for tobacco dependence: a focus on bupropion International Journal of Clinical Practice 55(1): 53-57
Walz, D.T.; DiMartino, M.J.; Griswold, D.E. 1982: Comparative pharmacology and biological effects of different gold compounds Journal of Rheumatology. Suppl 8: 54-60
Hertrich, O. 1983: Ataractic treatment in psychiatry and general medicine. Neuroleptics and thymoleptics. 3.1 Neuroleptics Fortschritte der Medizin 101(40): 1823; 1826-1827
Muggia, F.M.; Muderspach, L. 1994: Platinum compounds in cervical and endometrial cancers: focus on carboplatin Seminars in Oncology 21(2 Suppl 2: 35-41; Quiz 42, 58
Wasilewski, J.; Pasyk, S. 1991: Scintigraphy of the heart--a new generation of radiopharmaceutical agents, Technetium 99m-labeled isonitrile compounds Kardiologia Polska 34(1): 33-38
Almér, L.O. 1980: Vascular fibrinolytic activity in long term treatment with second generation sulfonylurea compounds Acta Endocrinologica. Supplementum 239: 53-55
Ueda, M.; Joshi, I.D.; Dan, M.; Uberti, J.P.; Chou, T.H.; Sensenbrenner, L.L.; Lum, L.G. 1993: Preclinical studies for adoptive immunotherapy in bone marrow transplantation. Generation of anti-CD3 activated cytotoxic T cells from normal donors and autologous bone marrow transplant candidates Transplantation 56(2): 351-356