The pharmacology of antidepressants at the synapse: focus on newer compounds
Richelson, E.
Journal of Clinical Psychiatry 55(Suppl): 34-39; Discussion 40-1, 98-100
1994
ISSN/ISBN: 0160-6689 PMID: 7961541 Document Number: 439080
This paper reviews the in vitro effects of antidepressants on blockade of uptake of norepinephrine, serotonin, and dopamine at the synapse (rat synaptosomal preparations), as well as blockade of histamine H-1, muscarinic, alpha-1-adrenergic, and dopamine D-2 receptors in human brain tissue. The potency of an antidepressant at this blockade is predictive of the likelihood of its causing certain side effects and drug-drug interactions.