Reducing effect of 3,4',5-trihydroxystibene-3-beta-mono-D-glucoside on arterial thrombosis induced by vascular endothelial injury
Wang, Y.Z.; Luo, S.F.; Zhang, P.W.; Yu, C.L.
Zhongguo Yao Li Xue Bao 16(2): 159-162
1995
ISSN/ISBN: 0253-9756 PMID: 7597920 Document Number: 454421
AIM: To study the effect of 3,4',5-trihydroxystibene- 3-beta-mono-D-glucoside (Polydatin, Pol) on rabbit arterial thrombosis. METHODS: Rabbit arterial thrombosis was induced by vascular endothelial damage with trypsin. RESULTS: It was showed that the moist weights of the thrombus were 6.6+-1.8 and 4.8+-1.6 mg in Pol 5 and 10 mg cntdot kg-1 groups, respectively, which was lighter than that in control (10.9+-1.9 mg, P lt 0.05, P lt 0.01); the platelet aggregation was inhibited simultaneously. In vitro, Pol 0.30-1.15 mmol cntdot L-1 reduced TXA-2 produced in platelets. It did not affect the production of PGI-2 in cultured human umbilical vein endothelial cells. CONCLUSION: Thrombosis was abated by Pol. The selective inhibition of production of TXA-2 rather than PGI-2, is one of the mechanisms involved.