Does renal impairment protect from gout?
Youssef, P.; Brama, T.; York, H.; Pickard, P.; Stewart, P.; McGill, N.
Journal of Rheumatology 22(3): 494-496
1995
ISSN/ISBN: 0315-162X PMID: 7783068 Document Number: 454286
Objective: To test whether renal impairment protects from the development of gout. Methods: We conducted a retrospective cohort study in which 40 hyperuricemic patients (serum uric acid gt 0.54 mM/l) with renal impairment (serum creatinine gt 200 mu-M/l) and 40 equally hyperuricemic patients with normal renal function (serum creatinine lt 120 mu-M/l) were given a telephone questionnaire eliciting a history of gout, its pattern and severity, and other features of medical and family history. Results: There was no significant difference among the prevalence of gout (relative risk 1.1, confidence interval 0.73-1.67), the pattern and severity of gout, and the presence of tophi between the 2 groups. A positive family history of gout was significantly increased in the patients with gouty arthritis (p lt 0.05). Conclusion: Renal impairment does not protect from gout. There may be a familial factor in the development of gout that is independent from the familial tendency for hyperuricemia.