Mortality studies in systemic lupus erythematosus. Results from a single center. II. Predictor variables for mortality
Abu-Shakra, M.; Urowitz, M.B.; Gladman, D.D.; Gough, J.
Journal of Rheumatology 22(7): 1265-1270
1995
ISSN/ISBN: 0315-162X PMID: 7562756 Document Number: 454074
Objective: To analyze the factors associated with mortality in patients with systemic lupus erythematosus (SLE), followed prospectively in a single center. Methods: The study included 665 patients with SLE followed over a 20-year period according to a standard protocol. Clinical laboratory information has been entered into a database. Univariate analysis was carried out to identify prognostic factors of death. The Cox proportional hazard regression model was used to estimate risk ratio of death. Results: Renal damage, thrombocytopenia, lung involvement, systemic lupus erythematosus disease activity index (SLEDAI) gtoreq 20 at presentation, and age gtoreq 50 at diagnosis were predictive factors for mortality in the univariate as well as in the multivariate analyses. Hypertension and ischemic heart disease were significantly associated with death only in the univariate analysis. Conclusion: Renal damage, thrombocytopenia, SLEDAI gtoreq 20 at presentation, lung involvement, and age gtoreq 50 at diagnosis are prognostic factors associated with mortality.