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Effectiveness of local in vivo application of bleomycetin (bleomycin) , chemosorbed on ion exchange medical gauze

Tikhomirov, G.A.; Bukhman, V.M.; Prigozhina, M.M.; Ryltsev, V.V.; Filatov, V.N.

Antibiotiki i Khimioterapiia 40(6): 19-22

1995

ISSN/ISBN: 0235-2990
PMID: 8593089
Document Number: 454011
Possible local application of a new dosage form of bleomycetin (bleomycin) with the prolonged action was studied in experimental in vivo models. When the ion exchange textile polymer with the immobilized bleomycetin was implanted subcutaneously to tumor-bearing mice, there was observed marked inhibition of the growth of the following tumors: lung carcinomatosis (LLC), melanoma B-16 and lympholeukemia (NK/Ly). The implants proved to be less toxic by comparison to bleomycetin solutions. The new bleomycetin dosage form is useful as a new delivery system increasing the antibiotic selective action.

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Grau, J.J.; Cuchi, A.; Estapé, J.; Arias, C.; Mañé, J.M.; Fírvida, J.L.; Moreno, F.; Traserra, J. 1996: Survival after chemotherapy with cisplatin and infusion of bleomycin prior to local-regional treatment in pyriform sinus cancer Tumori 82(3): 221-224
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Lazo, J.S.; Chen, D.L.; Gallicchio, V.S.; Hait, W.N. 1986: Increased lethality of calmodulin antagonists and bleomycin to human bone marrow and bleomycin-resistant malignant cells Cancer Research 46(5): 2236-2240
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