Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness
Chari, D.M.; Ramesh, V.; John, J.; Kumar, V.M.
Indian Journal of Physiology and Pharmacology 39(3): 299-301
1995
ISSN/ISBN: 0019-5499 PMID: 8550132 Document Number: 451332
Intracerebral microinjections of gamma amino butyric acid were given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotransmitter in the genesis and regulation of sleep-wakefulness. GABA (50 micrograms/0.2 microliters) when administered through chronically implanted cannulae in free moving rats, did not produce any significant alterations in sleep-wakefulness. This may be attributed either to the non-involvement of GABA at the level of mPOA in the regulation of sleep, or to other factors like the low dose and rapid breakdown of the injected drug.