The antianginal action of calcium antagonists: the results of instrumental examination and their clinical assessment
Karpov, R.S.; Mordovin, V.F.; Pavliukova, E.N.; Chernov, V.I.; Krylov, A.L.
Eksperimental'naia i Klinicheskaia Farmakologiia 58(2): 7-10
1995
ISSN/ISBN: 0869-2092 PMID: 7773098 Document Number: 451256
In 88 patients with coronary heart disease and stable exercise-induced angina pectoris, the efficiency of calcium antagonists was examined by using myocardial Tl-199 scintigraphy and comparing its data with the parameters of angiography and their intracoronary injection. Three types of therapy-induced changes in myocardial perfusion were identified, which were as follows: 1) significant decreases in hypoperfusion area dimensions; 2) no changes in scintigraphic parameters, and 3) clinically asymptomatic increases in the number of hypoperfused sectors. There was a relationship between the therapy-induced changes and the number of sclerotic arteries though the ability of large coronary vessels to dilate was substantially decreased, as shown by angiopharmacological studies.