An intraperitoneal tumorous mass caused by granulomas of microfibrillar collagen hemostat (Avitene)
Nakajima, M.; Kamei, T.; Tomimatu, K.; Manabe, T.
Archives of Pathology and Laboratory Medicine 119(12): 1161-1163
1995
ISSN/ISBN: 0003-9985 PMID: 7503666 Document Number: 451083
Microfibrillar collagen hemostat (Avitene) is an absorbable topical hemostatic agent prepared from purified bovine corium collagen. Herein, we report the case of a 56-year-old woman who had undergone an ovariohysterectomy for an ovarian mucinous cystadenocarcinoma 3 months previously and then required a second operation for an intraperitoneal mass associated with microfibrillar collagen hemostat. Microscopically, the resected mass was composed mostly of foreign-body granulomas with microfibrillar collagen hemostat materials. Microfibrillar collagen hemostat was used to control bleeding during the first operation. In a very small portion, however, a recurrent mucinous cystadenocarcinoma was also present. This case is worthy of note in that microfibrillar collagen hemostat may produce huge granulomatous masses that clinically mimic a neoplasm, inducing unnecessary and extensive treatment.