Absorption behavior of sulpiride described using Weibull functions
Rietbrock, S.; Merz, P.G.; Fuhr, U.; Harder, S.; Marschner, J.P.; Loew, D.; Biehl, J.
International Journal of Clinical Pharmacology and Therapeutics 33(5): 299-303
1995
ISSN/ISBN: 0946-1965 PMID: 7655770 Document Number: 450888
Deconvolution absorption profiles of oral sulpiride formulations were calculated from plasma concentration-time data obtained in an open, 3-period study with a crossover of the 2 oral formulations in 12 healthy volunteers following single intravenous (100 mg) and oral (2 times 50 mg capsules, 200 mg tablets) application of sulpiride. A model based on 2 Weibull-functions, and applied using NONMEM, described the complex absorption profiles more satisfactorily than a first order absorption model or a model based on a single Weibull-function.