The characteristics of the immunological indices in multiple myeloma during polychemotherapy
Abdulkadyrov, K.M.; Bessmel'tsev, S.S.
Likars'ka Sprava 1995(3-4): 75-80
1995
ISSN/ISBN: 1019-5297 PMID: 8819928 Document Number: 450702
Characteristics are presented of indices for immunologic reactivity in 90 patients with multiplex myeloma. It has been ascertained that in multiplex myeloma there is an imbalance of immunoregulatory cells, increase in the level of circulating immune complexes and the blood serum complementary activity. The most clear-cut deviations from the norm were recordable in B-cellular link of immunity. The patients were assigned to treatment with regimens according to a particular programme in chemotherapy. During the course of treatment the immunologic parameters were getting corrected. But VAD (vincristin+adriamicin+ dexamethasone) -- therapy was associated with suppression of T- and B-cellular link of immunity, which fact was one of the reasons of frequent infectious complications. On the basis of the previous immunologic investigation, the most efficaceous chemotherapy programme is that of VAD.