Lipidemic effect as a manifestation of chloroquine retinotoxicity
Gaafar, K.M.; Abdel-Khalek, L.R.; el-Sayed, N.K.; Ramadan, G.A.
Arzneimittel-Forschung 45(11): 1231-1235
1995
ISSN/ISBN: 0004-4172 PMID: 8929246 Document Number: 449394
The effect of long-term treatment of chloroquine (CAS 54-05-7) (20 mg/kg body weight) on serum lipid components and its relation to to the retinotoxic effect was studied in albino rats. Chloroquine was found to form lamellar lysosome-like structures within the photoreceptive layer, as well as the pigment epithelium and neurooretinal layers. Biochemically, hypolipidemia in the serum was observed mainly due to the decrease in phospholipid portion. It was hypothesized that due to the inhibition of the degradation process in the defective lysosomes, the retinal cells were denied the re-use of their own phospholipids, and thereby resort to their uptake from the serum.