Methazid-induced vitamin B2 deficiency in rats and its prevention
Kodentsova, V.M.; Kovalenko, T.A.; Vrzhesinskaya, O.A.; Kharitonchik, L.A.; Spirichev, V.B.
Ukrainskii Biokhimicheskii Zhurnal 67(6): 86-88
1995
ISSN/ISBN: 0201-8470 PMID: 8867318 Document Number: 449010
It has been estimated that ten-day rectal administration of metazid in the form of suppositories (20 mg per 100 g of body mass) gives rise to vitamin B-2 deficiency both in rats with initial vitamin B-2 insufficiency and in those adequately supplied. This is confirmed by a decrease in the vitamin B-2 content both in the liver aid in the blood plasma. Development and use of suppositories containing combined preparation of metazid and riboflavin (in the dose of 100 mu-g per a rat according to the daily recommended allowance) completely prevent metazid-induced vitamin B-2 deficiency.