Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?
Pickkers, P.; Schachter, M.; Sever, P.S.; Hughes, A.D.
Journal of Human Hypertension 9(8): 691-693
1995
ISSN/ISBN: 0950-9240 PMID: 8523393 Document Number: 448883
Thiazide diuretics are widely used to treat hypertension, but their use is associated with impaired glucose tolerance. We propose that the diabetogenic action of thiazides may be due to their ability to open calcium-activated potassium (KCa) channels in pancreatic beta-cells.
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