The presence of HIV DNA in the neutrophils of persons infected with the human immunodeficiency virus and the clinical parallels of this phenomenon
Gabrilovich, D.I.; Vasilev, V.B.; Nosikov, V.V.; Serebrovskaia, L.V.; Shepeleva, G.K.; Ivanova, L.A.; Pokrovskiĭ, V.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 5: 52-55
1995
ISSN/ISBN: 0372-9311 PMID: 8525734 Document Number: 447624
Relationships between some clinical data and the detection of human immunodeficiency virus (HIV) DNA in polymorphonuclear neutrophils (PMN) of 37 HIV-infected persons were studied. HIV DNA was determined with the use of polymerase chain reaction. The level of HIV DNA in PMN, sufficient for determination, was mostly detected in persons with clinical manifestations of HIV infection and less frequently in asymptomatic patients (46.7% and 18.2% respectively, p < 0.05). The significant relationship between the presence of HIV DNA in NP and a decrease in the CD4/CD8 ratio, as well as an increase in the level of immunoglobulins in the blood serum, has been established. The presence of HIV DNA in PMN was positively related to the decrease of the functional activity of these cells and the level of PMN in peripheral blood. The infection of PMN with HIV may be one of important mechanisms of their damage in HIV infection.