Hemodynamic effect of intrathecal clonidine
Rubin, L.; Koeberlé, P.; Bachour, K.; Bettinger, G.; Barale, F.
Cahiers d'Anesthesiologie 43(3): 307-312
1995
ISSN/ISBN: 0007-9685 PMID: 7583899 Document Number: 447572
Intrathecal administration of bupivacaine and clonidine results in a significant prolongation of both motor and sensitive blocks but side effects-hypotension and bradycardia-are observed. We compared two groups of patients allocated randomly. One group received intrathecal bupivacaine-morphine and the other one received clonidine-bupivacaine-morphine. In the group which received clonidine a blood pressure decrease was observed from 2nd to 8th hour, independently from the sympathetic block and easily corrected by i.v. ephedrine. Some possible explanations are discussed. No complications due to clonidine were observed.