CD-44 is not involved in the metastatic spread of ovarian cancer in vivo
Speiser, P.; Wanner, C.; Breitenecker, G.; Kohlberger, P.; Kainz, C.
Anticancer Research 15(6b): 2767-2769
1995
ISSN/ISBN: 0250-7005 PMID: 8669861 Document Number: 446638
It has been shown that isoforms of the adhesion molecule CD44 are involved in the metastatic spread of several human malignancies. To determine whether CD44 plays a role in metastasis of human ovarian cancer, the tumours and corresponding metastases of 28 patients were investigated. CD44 was detected by immunohistochemistry in 2 primary tumours (7.1%) and 3 metastases (10.7%). In no case did both the primary tumour and metastasis show CD44 expression simultaneously. The results presented here suggest that CD44 does not play a crucial role in the metastatic spread of human ovarian cancer.