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Epidermal growth factor (EGF) can induce prostatic buds in the absence of androgens

Saito, M.; Mizuno, T.

Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 189(4): 637-641

1995

ISSN/ISBN: 0037-9026
PMID: 8564578
Document Number: 445807
We have investigated the prostatic bud induction in the urogenital sinus of fetal rats and mice when the sinuses were cultured with non-androgenic growth factors, and found that epidermal growth factor (EGF) as well as transforming growth factor-alpha (TGF-alpha) powerfully induces the prostatic buds in the absence of androgens even in the androgen-receptor-deficient Tfm sinuses. Immunofluorescence study revealed that endogenous EGF and EGF receptor exist in the sinus mesenchyme of 19.5-day fetal male rats, where many prostatic buds are appearing.

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