Esters of cephalosporins. Part II. Differences in the properties of various forms of the 1-acetoxyethyl ester of cefuroxime
Oszczapowicz, I.; Małafiej, E.; Szelachowska, M.; Horoszewicz-Małafiej, A.; Kuklewicz, C.; Sierańska, E.; Denys, A.; Niedworok, J.
Acta Poloniae Pharmaceutica 52(5): 397-401
1995
ISSN/ISBN: 0001-6837 PMID: 8960273 Document Number: 445348
Physico-chemical and microbiological properties of three different forms (crystalline and two amorphous ones) of the 1-acetoxyethyl ester of cefuroxime and bioavailability after oral administration to rats have been investigated. Relation between physico-chemical properties of these forms and their bioavailability is observed. It is shown, that for oral administration the most appropriate is an amorphous form obtained by rapid evaporation of a solvent from solution of the ester.