Some factors determining the minimum number of cells required for successful clinical engraftment
Gordon, M.Y.; Blackett, N.M.
Bone Marrow Transplantation 15(5): 659-662
1995
ISSN/ISBN: 0268-3369 PMID: 7670392 Document Number: 445161
Theoretically, a single pluripotent haemopoietic stem cell should be able to reconstitute haemopoiesis following transplantation. However, clinical and experimental observations demonstrate that it is necessary to transplant numerous stem cells to obtain engraftment. Here we discuss some of the reasons for this apparent discrepancy and provide some quantitative estimates of the influence of kinetic factors in determining the number of stem cells required for clinical engraftment.