Short report: detection of 72-75-kD and 123-kD fractions of Leishmania antigen in urine of patients with visceral leishmaniasis
De Colmenares, M.; Portus, M.; Riera, C.; Gallego, M.; Aisa, M.J.; Torras, S.; Munoz, C.
American Journal of Tropical Medicine and Hygiene 52(5): 427-428
1995
ISSN/ISBN: 0002-9637 PMID: 7539596 Document Number: 445067
Two polypeptide fractions of 72-75 kD were detected in the urine of 14 of 15 patients with visceral leishmaniasis (VL) and another fraction of 123 kD was found in 10 of the 15 patients by using a Western blot technique. None of these fractions was detected in the urine of 20 controls. These results suggest that antigen detection in urine could be a powerful, noninvasive method for VL diagnosis.
Document emailed within 1 workday
Related Documents
Badaro, R.; Eulalio, M.C.; Benson, D.; Freire, M.; Miranda, J.C.; Pedral-Sampaio, D.; Burns, J.M.; David, J.R.; Johnson, W.D.; Reed, S.G. 1993: Sensitivity and specificity of a recombinant Leishmania chagasi antigen in the serodiagnosis of visceral leishmaniasis Archives de l'Institut Pasteur de Tunis 70(3-4): 331-332Gelanew, T.; Hurissa, Z.; Diro, E.; Kassahun, A.; Kuhls, K.; Schönian, G.; Hailu, A. 2011: Disseminated cutaneous leishmaniasis resembling post-kala-azar dermal leishmaniasis caused by Leishmania donovani in three patients co-infected with visceral leishmaniasis and human immunodeficiency virus/acquired immunodeficiency syndrome in Ethiopia American Journal of Tropical Medicine and Hygiene 84(6): 906-912
Carnaúba, D.; Konishi, C.Tami.; Petri, Véria.; Martinez, I.Cristina.Pedro.; Shimizu, L.; Pereira-Chioccola, V.Lucia. 2009: Atypical disseminated leishmaniasis similar to post-kala-azar dermal leishmaniasis in a Brazilian AIDS patient infected with Leishmania (Leishmania) infantum chagasi: a case report International Journal of Infectious Diseases: Ijid: Official Publication of the International Society for Infectious Diseases 13(6): E504-E507
Batra, D.; Lin, W.; Narayanan, V.; Rowe, L.A.; Sheth, M.; Zheng, Y.; Loparev, V.; de Almeida, M. 2019: Draft Genome Sequences of Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) mexicana, and Leishmania (Leishmania) aethiopica, Potential Etiological Agents of Diffuse Cutaneous Leishmaniasis Microbiology Resource Announcements 8(20)
Nandy, A.; Addy, M.; Maji, A.K.; Guha, S.K. 2004: Impact of a co-factor on the dynamics of Leishmania donovani infection: does HIV infection encourage the recurrence of visceral leishmaniasis following post-kala-azar dermal leishmaniasis? Annals of Tropical Medicine and Parasitology 98(6): 651-654
Maharom, P.; Siripattanapipong, S.; Mungthin, M.; Naaglor, T.; Sukkawee, R.; Pudkorn, R.; Wattana, W.; Wanachiwanawin, D.; Areechokchai, D.; Leelayoova, S. 2008: Visceral leishmaniasis caused by Leishmania infantum in Thailand Southeast Asian Journal of Tropical Medicine and Public Health 39(6): 988-990
Srivastava, J.K.; Misra, A.; Sharma, P.; Srivastava, B.; Naik, S.; Dube, A. 2003: Prophylactic potential of autoclaved Leishmania donovani with BCG against experimental visceral leishmaniasis Parasitology 127(Pt 2): 107-114
Mary, C.; Ange, G.; Dunan, S.; Lamouroux, D.; Quilici, M. 1993: Characterization of a circulating antigen involved in immune complexes in visceral leishmaniasis patients American Journal of Tropical Medicine and Hygiene 49(4): 492-501
Rachamim, N.; Jaffe, C.L. 1993: Pure protein from Leishmania donovani protects mice against both cutaneous and visceral leishmaniasis Journal of Immunology 150(6): 2322-2331
Paolini, O.; Marty, P.; Dassonville, O.; Duplay, H.; Saint-Paul, M.C.; Carlotti, B.; Poissonnet, G.; Demard, F. 1993: Intra-parotid nodule caused by Leishmania in a case of apparently cured visceral leishmaniasis Presse Medicale 22(23): 1107
Bradley, D.J.; Taylor, B.A.; Blackwell, J.; Evans, E.P.; Freeman, J. 1979: Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse Clinical and Experimental Immunology 37(1): 7-14
Sreenivas, G.; Ansari, N.A.; Singh, R.; Subba Raju, B.V.; Bhatheja, R.; Negi, N.S.; Salotra, R. 2002: Diagnosis of visceral leishmaniasis: comparative potential of amastigote antigen, recombinant antigen and PCR British Journal of Biomedical Science 59(4): 218-222
Albrecht, H.; Sobottka, I.; Emminger, C.; Jablonowski, H.; Just, G.; Stoehr, A.; Kubin, T.; Salzberger, B.; Lutz, T.; van Lunzen, J. 1996: Visceral leishmaniasis emerging as an important opportunistic infection in HIV-infected persons living in areas nonendemic for Leishmania donovani Archives of Pathology and Laboratory Medicine 120(2): 189-198
Peterslund, N.A.; Pallesen, G.; Bertel, L. 1982: Visceral leishmaniasis (kala-azar). Report of a case of infantile Mediterranean leishmaniasis Ugeskrift for Laeger 144(40): 2948-2949
Islam, M.Zahidul.; Itoh, M.; Mirza, R.; Ahmed, I.; Ekram, A.R.M.Saifuddin.; Sarder, A.Halim.; Shamsuzzaman, S.M.; Hashiguchi, Y.; Kimura, E. 2004: Direct agglutination test with urine samples for the diagnosis of visceral leishmaniasis American Journal of Tropical Medicine and Hygiene 70(1): 78-82
Roig, P.; Cuadrado, J.M.; Benéitez, C.; Mayol, M.J.; López, M.; Navarro, V.; Nieto, A.; Bernacer, B. 1993: Visceral leishmaniasis located in the intestines in patients with human immunodeficiency virus infection: a report of 2 cases Revista Clinica Espanola 192(6): 271-273
Ashford, D.A.; Badaro, R.; Eulalio, C.; Freire, M.; Miranda, C.; Zalis, M.G.; David, J.R. 1993: Studies on the control of visceral leishmaniasis: validation of the Falcon assay screening test--enzyme-linked immunosorbent assay (FAST-ELISA) for field diagnosis of canine visceral leishmaniasis American Journal of Tropical Medicine and Hygiene 48(1): 1-8
Kahl, L.P.; Scott, C.A.; Lelchuk, R.; Gregoriadis, G.; Liew, F.Y. 1989: Vaccination against murine cutaneous leishmaniasis by using Leishmania major antigen/liposomes. Optimization and assessment of the requirement for intravenous immunization Journal of Immunology 142(12): 4441-4449
Webb, J.R.; Kaufmann, D.; Campos-Neto, A.; Reed, S.G. 1996: Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis Journal of Immunology 157(11): 5034-5041
Mansueto, S.; Migneco, G.; La Cascia, C. 1979: The complement fixation test in leishmaniasis. Comparison between an antigen extracted from leishmania cultures and one extracted from BCG Minerva Medica 70(38): 2611-2614