Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse
Bradley, D.J.; Taylor, B.A.; Blackwell, J.; Evans, E.P.; Freeman, J.
Clinical and Experimental Immunology 37(1): 7-14
1979
ISSN/ISBN: 0009-9104 PMID: 290436 Document Number: 146757
Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the chromosome-1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome-1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicated that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 plus or minus 0.04. This mapping places Lsh away from the known histocompatibility loci. [For Pt. II see ABA 46 2870]. Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the chromosone I marker Id-I was detected using several nets of recombinant inbred strains. Chromosome I linkage was confirmed in backcross generations using isoenzymes and a cytogentic marker. The data indicate that the gene order is centromere-Lsh-Id-I in 1n-Dip-1. The estimated recombination frequency between Lsh and Id-I is 0.12 plus or minus 0.04. This mapping is always from the known histocompatibility loci. [AS].