A case of acute megakaryoblastic leukaemia with t (X;6) (p11.21;q23) having an X chromosome breakpoint within a 450-Kb region which is also disrupted in two classes of solid tumours
Reeves, B.R.; Knight, J.C.; Renwick, P.J.; Jani, K.; Kempski, H.
Leukemia 9(4): 723-725
1995
ISSN/ISBN: 0887-6924 PMID: 7723409 Document Number: 443610
Karyotype analysis of a case of acute megakaryoblastic leukaemia revealed an X;6 translocation as the sole abnormality. Using fluorescence in situ hybridization on leukaemic metaphases we demonstrated that the breakpoint on the X-chromosome occurred at p11.21, within a region spanned by a YAC probe which has also been found to be disrupted in synovial sarcomas and some papillary renal cell carcinomas.
Document emailed within 1 workday
Related Documents
Bidwai-Bhattacharjee, M.; Shome, D.K.; Srinivas, M.; Ghosh, K.; Verma, S.; Mohanty, D.; Bhagwat, A.G.; Das, K.C. 1986: Acute megakaryoblastic leukaemia--an underdiagnosed entity Indian Journal of Cancer 23(2): 75-82Benn, P.; Grossman, A.; Soper, L.; Halka, K.; Eisenberg, A.; Gascon, P. 1988: A rare restriction enzyme site polymorphism in the breakpoint cluster region (bcr) of chromosome 22 Leukemia 2(11): 760-762
Paulien, S.; Turc-Carel, C.; Dal Cin, P.; Jani-Sait, S.; Sreekantaiah, C.; Leong, S.P.; Vogelstein, B.; Kinzler, K.W.; Sandberg, A.A.; Gemmill, R.M. 1990: Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12 Cancer Research 50(24): 7902-7907
Löchner, K.; Siegler, G.; Führer, M.; Greil, J.; Beck, J.D.; Fey, G.H.; Marschalek, R. 1996: A specific deletion in the breakpoint cluster region of the ALL-1 gene is associated with acute lymphoblastic T-cell leukemias Cancer Research 56(9): 2171-2177
Laureys, G.; Speleman, F.; Versteeg, R.; van der Drift, P.; Chan, A.; Leroy, J.; Francke, U.; Opdenakker, G.; Van Roy, N. 1995: Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers Oncogene 10(6): 1087-1093
Rowley, J.D. 1993: Rearrangements involving chromosome band 11Q23 in acute leukaemia Seminars in Cancer Biology 4(6): 377-385
Tang, Y.-L.; Raja Sabudin, R.Z.A.; Leong, C.-F.; Ko, C.C.-H.; Chia, W.-K.; Salwati, S.; Wong, C.-L. 2015: Double Philadelphia chromosome-positive B acute lymphoblastic leukaemia in an elderly patient Malaysian Journal of Pathology 37(3): 275-279
Van 't Veer, M.B. 1990: Chromosome 14: a breakpoint in non-Hodgkin's lymphomas Netherlands Journal of Medicine 37(1-2): 37-43
Stopera, S.A.; Ray, M. 1989: Expression and distribution of aphidicolin-induced fragile sites in chronic myeloid leukaemia, acute lymphocytic leukaemia and acute myeloid leukaemia Cytobios 60(241): 103-109
Chevillard, S.; Vielh, P.; Validire, P.; Marie, J.P.; Faussat, A.M.; Barbu, V.; Bayle, C.; Bénard, J.; Bonnal, C.; Boutonnat, J.; Calvo, F.; Charrier, J.; Clary, A.; Colosetti, P.; Danel-Moore, L.; Decrémoux, P.; Delvincourt, C.; Finat-Duclos, F.; Genne, P.; Kataki, A.; Kouyoumdjian, J.C.; Lacave, R.; Maugard, C.; Merlin, J.L.; Robert, J. 1997: French multicentric evaluation of mdr1 gene expression by RT-PCR in leukemia and solid tumours. Standardization of RT-PCR and preliminary comparisons between RT-PCR and immunohistochemistry in solid tumours. French Network of the Drug Resistance Intergroup, and Drug Resistance Network of Assistance Publique-Hôpitaux de Paris Leukemia 11(7): 1095-1106
Tange, T.; Nakahara, K.; Mitani, K.; Yamasaki, I.; Yasuda, H.; Tanaka, F.; Mizuguchi, M.; Oda, H.; Yatomi, Y.; Takanashi, R. 1988: Establishment of a human megakaryoblastic cell line (T-33) from chronic myelogenous leukemia in megakaryoblastic crisis Cancer Research 48(21): 6137-6144
Graham, M.; Adams, J.M. 1986: Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus EMBO Journal 5(11): 2845-2851
Moedjono, S.J.; Sparkes, R.S. 1980: Familial pericentric inversion of chromosome 8 : is breakpoint p22q23 important in the formation of unbalanced recombinants? Annales de Genetique 23(4): 235-237
Corradini, P.; Palumbo, A.P.; Battaglio, S.; Ponzio, G.; Boccadoro, M.; Pileri, A. 1990: Analysis of the breakpoint cluster region in essential thrombocythemia Haematologica 75(6): 573-575
Quaglino, D.; Lusvarghi, E.; Piccinini, L.; di Prisco, A.U.; Guerzoni, O.; Mauri, C. 1976: The association between chronic lymphocytic leukaemia and a solid tumor: a survey study of 258 cases of chronic lymphocytic leukaemia covering an eleven year period Haematologica 61(4): 456-469
Dawani, K.; Tayyab, M. 1992: Immunoglobulin classes G,A,M in brain tumours Jpma. Journal of the Pakistan Medical Association 42(7): 157-158
Brissenden, J.E.; Derynck, R.; Francke, U. 1985: Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation Cancer Research 45(11 Pt 2): 5593-5597
Michalski, A.J.; Cotter, F.E.; Cowell, J.K. 1992: Isolation of chromosome-specific DNA sequences from an Alu polymerase chain reaction library to define the breakpoint in a patient with a constitutional translocation t(1;13) (q22;q12) and ganglioneuroblastoma Oncogene 7(8): 1595-1602
Lange, D.; Kup, W. 1973: Malignant tumours in the ENR-region. IV. Tumours of the parotis gland Archiv für Geschwulstforschung 42(4): 358-371
Robak, T. 1987: Acute megakaryoblastic leukemia FAB M7 Acta Haematologica Polonica 18(3-4): 179-186