The kinetics of 5-fluorocytosine elimination in man
Wade, D.N.; Sudlow, G.
Australian and New Zealand Journal of Medicine 2(2): 153-158
1972
ISSN/ISBN: 0004-8291 PMID: 4507092 Document Number: 44342
Using 5-fluorocytosine-2-14C, the plasma and urinary clearances of 5-FC were measured together with simultaneous inulin clearances. In 8 healthy subjects the drug was shown to be eliminated largely by the kidney, 90% of an intravenous load being recovered as unchanged drug in the urine within 48 h. A formula is presented to calculate 5-FC dosages in patients with renal insufficiency.
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